SMAC Antibody (Clone AT19F2)

Categories: [ Antibodies][ Monoclonal Antibodies]

SMAC/Diablo is one of the proapoptotic proteins. SMAC promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding to inhibitor of apoptosis proteins (IAPs) and removing their inhibitory activity. In healthy cells, SMAC is a mitochondrial protein, but when cells undergo apoptosis, SMAC is released into the cytosol. SMAC is ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes.

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Properties

Data Sheet	Click for Datasheet
Catalog Number	MA01587
Size	100 µL
Host Type	Mouse
Immunogen	Recombinant human SMAC/Diablo (56-239aa) purified from E. coli
Specificity
Isotype	Mouse IgG2a heavy chain and kappa light chain
Reacitivity	Human
Clone	Anti-human SMAC mAb, clone AT19F2, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human SMAC/Diablo protein.
Uniprot
Concentration	1 mg/ml
Dilution
Formulation	Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.
Application	ELISA, WB, ICC/IF, Flow cytometry
Other Names
Storage	Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript	For research use only, not for use in diagnostic procedures.

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SMAC Antibody (Clone AT19F2)

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