sAPPβ-sw (6A1) Anti-Human Mouse IgG MoAb

Amyloidβ is derived by the sequential cleavage of amyloid precursor protein (APP) by betaand gamma-secretases. A double missense mutation (Lys670→Asn and Met671→Leu) in APP found in a Swedish pedigree (APPβ-sw) elevates Abeta40 and Abeta42 production (1), and the mutation is utilized in establishment of transgenic mice overexpress a mutant form of human amyloid precursor protein (2). Amyloidβproduction and, beta-secretase cleavage of APP β -sw reportedly occur in the endoplasmic reticulum (ER), Golgi and endocytic compartments (3).
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Properties

Data Sheet Click for Datasheet
Catalog Number MA01092
Size 100 μg
Host Type Mouse
Immunogen Synthetic peptide for C-Terminal of Human sAPPβ-sw (ISEVNL)
Specificity
Isotype IgG3
Reacitivity Human
Clone 6A1
Uniprot
Concentration Please see datasheet.
Dilution
Formulation Lyophilized product from 1% BSA in PBS containing 0.05%NaN3
Application WB, Immunoprecipitation.
Other Names Soluble βAmyloid Precursor Protein -Swedish
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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