NP95 (mt40) Anti-Human Mouse IgG MoAb

Np95 has been originally found as a tumor-specific nuclear antigen of 95kDa in mice. Experiments using B10 strains showed that Np95 is enriched in precancerous cells and is abnormally expressed throughout cell cycle in radiation-induced lymphomatoid cells. Recent attention is put on the epigenetic role of Np95, which mediates the interplay between DNA methylase and hemi-methylated sites to maintain DNA methylation patterns at replication forks. This antibody is available for detection of the human nucleoprotein NP95 (also known as UHRF1), whose function is dependent on S-phase in non-neoplastic cells but could be modified with abberant cell cycle during tumorigenesis.