EPCAM Antibody (Clone AT37F9)

Categories: [ Antibodies][ Monoclonal Antibodies]

Epithelial cell adhesion molecule (EPCAM) is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell-cell adhesion in epithelia. EPCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EPCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E. Since EPCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EPCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies.

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Properties

Data Sheet	Click for Datasheet
Catalog Number	MA01237
Size	100 µL
Host Type	Mouse
Immunogen	Recombinant human EPCAM (24-265aa) purified from E. coli
Specificity
Isotype	IgG1,k
Reacitivity	Human
Clone	Anti-human EPCAM mAb, clone AT37F9, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human EPCAM protein.
Uniprot
Concentration	1mg/ml
Dilution
Formulation	Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.
Application	ELISA, WB.
Other Names	Epithelial cell adhesion molecules, CD326, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1, DIAR5, EGP, GA733 2, HNPCC8.
Storage	Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript	For research use only, not for use in diagnostic procedures.

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EPCAM Antibody (Clone AT37F9)

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