c-MPL-P(M617) Anti-Human Rabbit IgG Affinity Purify

The c-mpl proto oncogene was first identified as the cellular homolog of the viral oncogene v-mpl in the myeloproliferative leukemia virus (MPLV). However, based on homology with a member of the cytokine receptor superfamily, the c-mpl gene was predicted to encode a receptor for some cytokine. An antisense oligomer against c-mpl selectively inhibited megakaryocytic colony formation. Moreover, c-mpl-deficient mice had selectively dramatic decrease in the number of circulating platelets and megakaryocytes in the spleen and bone marrow. Collectively, these observations suggested that the c-Mpl ligand is identical to thrombopoietin (TPO). Several groups have purified TPO as the c-Mpl ligand. In fact, in vitro and in vivo studies have shown that recombinant TPO alone can support the proliferation and differentiation of megakaryocyte progenitor cells and maturation of megakaryocyte. There are two types of alternatively spliced isoforms of c-mpl, c-mpl-P (wild type) and c-mpl-K (truncated).
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01080
Size 25 µg
Host Type Rabbit
Immunogen Synthetic peptide of the C terminal part of Human c-MPL-P
Specificity Reacts to UT-7/TPO (ref. 1)
Isotype
Reacitivity Human
Clone
Uniprot
Concentration
Dilution
Formulation Form : Lyophilized product from 1 % BSA in PBS containing 0.05% NaN3
Application WB.
Other Names
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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