BUB3 Monoclonal Antibody (Clone AT2H6)

BUB3 (budding uninhibited by benzimidazoles 3 homolog) is a conserved component of the mitotic spindle assembly complex (MCC). It contains five WD repeat domains and forms cell cycle constitutive complexes with BUB1 and BUBR1. BUB3 is essential for the kinetochore localization of BUB1 and BUBR1. As a component of the MCC, BUB3 is involved in the essential spindle checkpoint pathway that operates during early embryogenesis. The spindle checkpoint pathway functions to postpone the initiation of anaphase until chromosomes are properly attached to the spindle. This acts to ensure accurate chromosome segregation. In addition, BUB3 plays a role in regulating the establishment of correct kinetochore-microtubule attachments.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA01123
Size 100 µL
Host Type
Immunogen Recombinant human BUB3 (1-328aa) purified from E. coli
Specificity
Isotype IgG2b,k
Reacitivity Human
Clone Anti-human BUB3 mAb, clone AT2H6, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human BUB3 protein.
Uniprot
Concentration 1 mg/mL
Dilution
Formulation Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol.
Application ELISA, WB.
Other Names Mitotic checkpoint protein BuB3, BuB3L, hBuB3
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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