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Anti-Human USP5 Monoclonal Antibody

Categories: [ Antibodies][ Monoclonal Antibodies]
USP5,also named as ISOT,belongs to the peptidase C19 family. Knock-down of USP5 causes the accumulation of TP53/p53 and an increase in TP53/p53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated TP53/p53 but not with MDM2 for proteasomal recognition. USP5 is a potential target for p53 activating therapeutic agents for the treatment of cancer. It is a novel proteasome associated protein. USP5 cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA02283
Size 100μl
Host Type Mouse
Immunogen Fusion protein of USP5
Specificity
Isotype IgG2a
Reacitivity Human
Clone 356
Uniprot P45974
Concentration None
Dilution WB 1:500-1:5000
Formulation
Application WB,ELISA
Other Names Deubiquitinating enzyme 5,Isopeptidase T,ISOT 1,ISOT,Ubiquitin carboxyl-terminal hydrolase 5,Ubiquitin isopeptidase T,Ubiquitin specific peptidase 5 (isopeptidase T),Ubiquitin specific peptidase 5,Ubiquitin specific processing protease 5,Ubiquitin specific protease 5 (isopeptidase T),Ubiquitin specific protease 5 (ubiquitin isopeptidase T),Ubiquitin thioesterase 5,Ubiquitin thiolesterase 5,Ubiquitin-specific-processing protease 5,UBP5,Usp5
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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