Anti-Human SPARC Monoclonal Antibody

SPARC,also known as ON (Osteonectin) or BM-40 (Basement-membrane protein 40),is an extracellular glycoprotein with the calculated molecular mass of 35 kDa and the apparent molecular mass of 40-43 kDa and 50 kDa . SPARC belongs to a group of matricellular proteins defined as secreted components that do not contribute directly to the formation of structural elements but serve to modulate cell-matrix interactions and cellular functions . SPARC is expressed at high levels in bone tissue,is distributed widely in many other tissues and cell types,and is associated generally with tissues undergoing morphogenesis,remodeling and wound repair . It elicits changes in cell shape,inhibits cell-cycle progression,and influences the synthesis of extracellular matrix . Altered expression of SPARC has been reported in a variety of cancers,which include breast,ovarian,colorectal,and pancreatic cancer as well as melanoma and glioblastomas .