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Anti-Human/Mouse/Rat SMAD7 Monoclonal Antibody

Categories: [ Antibodies][ Monoclonal Antibodies]
SMAD7,also named as Mothers against decapentaplegic homolog 7,is a 426 amino acid protein,which belongs to the dwarfin/SMAD family. SMAD7 Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:16601693). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (PubMed:17327236). SMAD7 as antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. SMAD7 functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex and also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1,which promotes its dephosphorylation. SMAD7 positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA02556
Size 100μl
Host Type Mouse
Immunogen Fusion Protein of SMAD7
Specificity Ubiquitous with higher expression in the lung and vascular endothelium.
Isotype IgG2b
Reacitivity Human,Mouse,Rat
Clone 2B9A4
Uniprot O15105
Concentration None
Dilution WB 1:500-1:2000
Formulation
Application WB,ELISA
Other Names CRCS3,FLJ16482,hSMAD 7,hSMAD7,MAD (mothers against decapentaplegic Drosophila) homolog 7,MAD,Mad homolog 7,MAD homolog 8,MAD mothers against decapentaplegic homolog 7,MADH 7,MADH 8,MADH6,MADH8,Mothers Against Decapentaplegic Drosophila Homolog of 6,Mothers Against Decapentaplegic Drosophila Homolog of 7,Mothers against decapentaplegic homolog 7,Mothers against decapentaplegic homolog 8,Mothers against DPP homolog 7,Mothers against DPP homolog 8,SMA- AND MAD-RELATED PROTEIN 7,SMAD 7,SMAD,SMAD family member 7,SMAD,mothers against DPP homolog 7 (Drosophila),SMAD,mothers against DPP homolog 7,SMAD6,Smad7,SMAD7
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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