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Anti-Human/Mouse/Rat Phospho-p21 (Thr145) Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01604
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human p21 around the phosphorylation site of Thr145
Specificity Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot P38936
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Formulation
Application WB,IHC-p,ELISA
Other Names CAP20,CDK-interacting protein 1,CDKI,CDKN1,Cdkn1a,CDN1A,CIP1,Cyclin Dependent Kinase Inhibitor 1A,Cyclin-dependent kinase inhibitor 1,Cyclin-dependent kinase inhibitor 1A (P21),Cyclin-dependent kinase inhibitor 1A (p21,Cip1),DNA Synthesis Inhibitor,MDA-6,MDA6,Melanoma differentiation-associated protein 6,Melanoma differentiation-associated protein,p21,P21 protein,p21CIP1,p21Cip1/Waf1,p21WAF,PIC1,SDI1,SLC12A9,WAF1,Wild type p53 activated fragment 1 (WAF1),Wild type p53 activated fragment 1,Wildtype p53-activated fragment 1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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