Anti-Human/Mouse/Rat PGR Monoclonal Antibody

Categories: [ Antibodies][ Monoclonal Antibodies]

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.Isoform A: inactive in stimulating c-Src/MAPK signaling on hormone stimulation.Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

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Data Sheet	Click for Datasheet
Catalog Number	MA02595
Size	100μl
Host Type	Mouse
Immunogen	Synthetic Peptide
Specificity	In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region-specific responses to hormonal stimuli.
Isotype	IgG
Reacitivity	Human,Mouse,Rat
Clone	1A5
Uniprot	P06401
Concentration	1mg/mL
Dilution	IHC 1:100-1:300, IF 1:100-200
Formulation
Application	IHC-p,IF
Other Names	NR3C3,Nuclear receptor subfamily 3 group C member 3,PGR,PR,PRA,PRB,PRGR,Progesterone receptor,Progestin receptor form A,Progestin receptor form B
Storage	Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript	For research use only, not for use in diagnostic procedures.

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Anti-Human/Mouse/Rat PGR Monoclonal Antibody

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