Anti-Human/Mouse/Rat COMP Polyclonal Antibody

The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED).
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Properties

Data Sheet Click for Datasheet
Catalog Number PA12333
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human COMP
Specificity Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.
Isotype IgG
Reacitivity Human,Mouse,Rat
Clone
Uniprot P49747
Concentration 0.3 mg/mL
Dilution IHC 1:100-1:300
Formulation
Application IHC,ELISA
Other Names cartilage oligomeric matrix protein (pseudoachondroplasia,epiphyseal dysplasia 1,multiple),Cartilage oligomeric matrix protein,Cartilage oligomeric matrix protein precursor,COMP,COMP,EDM 1,EDM1,EPD 1,EPD1,Epiphyseal dysplasia 1,Epiphyseal dysplasia 1 multiple,Epiphyseal dysplasia multiple 1,MED,MGC13181,MGC149768,PSACH,pseudoachondroplasia (epiphyseal dysplasia 1,multiple),Pseudoachondroplasia,THBS 5,THBS5,Thrombospondin 5,Thrombospondin-5,Thrombospondin5,TSP5
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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