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Anti-Human/Mouse/Rat C9orf72 Monoclonal Antibody

Categories: [ Antibodies][ Monoclonal Antibodies]
C9ORF72 has a domain whith polymorphic hexanucleotide repeat (GGGGCC). The C9ORF72-hexanucleotide repeat expansions have been recently identified as genetic markers in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). FTLD-TDP has five subtypes: Sporadic FTLD,GRN mutation FTLD,TARDBP mutation FTLD,VCP mutation FTLD and C9ORF72 mutation FTLD. The C9ORF72 repeat expansions may indicate a worse prognosis in ALS. Human C9ORF72 has some isoforms with MW 54-60 kDa and 25-30 kDa. Mouse C9orf72 has some isoforms with MW 50-60 kDa and 35 kDa.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA01882
Size 100μl
Host Type Mouse
Immunogen Fusion protein of C9orf72
Specificity Both isoforms are widely expressed, including kidney, lung, liver, heart, testis and several brain regions, such as cerebellum. Also expressed in the frontal cortex and in lymphoblasts (at protein level).
Isotype IgG2a
Reacitivity Human,Mouse,Rat
Clone 38
Uniprot Q96LT7
Concentration None
Dilution WB 1:200-1:2000, IHC 1:20-1:200, IF 1:10-1:100
Formulation
Application WB,IHC,IF,ELISA
Other Names ALSFTD,C9orf72,chromosome 9 open reading frame 72,CI072,FTDALS,MGC23980,Protein C9orf72,RP11-27J8.2,Uncharacterized protein C9orf72
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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