Anti-Human/Mouse/Rat AKT1 Monoclonal Antibody

The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1,which then phosphorylates and inactivates components of the apoptotic machinery. This antibody detects all the members of AKT with/without phospho- modification.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA01845
Size 100μl
Host Type Mouse
Immunogen Fusion protein of AKT1
Specificity Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages.
Isotype IgG1
Reacitivity Human,Mouse,Rat
Clone 405
Uniprot P31749
Concentration None
Dilution WB 1:1000-1:10000, IHC 1:100-1:400, IF 1:10-1:100
Formulation
Application WB,IHC,IF,ELISA
Other Names AKT 1,AKT,AKT1,AKT1,MGC99656,PKB,PKB-ALPHA,PRKBA,Protein Kinase B Alpha,Protein kinase B,Proto-oncogene c-Akt,RAC Alpha,RAC,RAC-alpha serine/threonine-protein kinase,RAC-PK-alpha
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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