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Anti-Human/Mouse PIWIL1 Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms. The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA12592
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human PIWIL1
Specificity Detected in most fetal and adult tissues. Expressed in testes, specifically in germline cells; detected in spermatocytes and spermatids during spermatogenesis. Increased expression in testicular tumors originating from embryonic germ cells with retention of germ cells phenotype. No expression in testicular tumors of somatic origin, such as Sertoli cell and Leydig cell tumors. Overexpressed in gastric cancer cells. Isoform 3 is ubiquitously expressed, and specifically in CD34+ hematopoietic progenitor cells but not in more differentiated cells.
Isotype IgG
Reacitivity Human,Mouse
Clone
Uniprot Q96J94
Concentration 0.3 mg/mL
Dilution IHC 1:25-1:100
Formulation
Application IHC,ELISA
Other Names HIWI,MIWI,Piwi (Drosophila) like 1,PIWI,Piwi homolog,Piwi like 1 (drosophila),Piwi like 1,Piwi-like protein 1,PIWIL1,PIWL1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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