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Anti-Human/Mouse Phospho-RAD17 (Ser645) Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01654
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human Rad17 around the phosphorylation site of Ser645
Specificity Overexpressed in various cancer cell lines and in colon carcinoma (at protein level). Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level). Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors).
Isotype IgG
Reacitivity Human,Mouse
Clone
Uniprot O75943
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:5000
Formulation
Application WB,ELISA
Other Names CCYC,Cell cycle checkpoint protein,Cell cycle checkpoint protein RAD17,FLJ41520,HRAD 17,hRad17,R24L,Rad 17,Rad 24,RAD1 (S. pombe) homolog,RAD1 homolog,RAD17,RAD17 homolog (S. pombe),RAD17 homolog,Rad17 like protein,RAD17,S. pombe,homolog of,RAD17,RAD17Sp,Rad24,Rad24,mouse,homolog of,Rad24,S. cerevisiae,homolog of,RF C activator 1 homolog,RF C/activator 1 homolog,RF-C/activator 1 homolog
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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