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Anti-Human/Mouse Phospho-EPHA2 (Tyr588) Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]
Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Induces apoptosis in a p53/TP53-independent, caspase-8-dependent manner.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01551
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from human EphA2 around the phosphorylation site of Tyr588
Specificity Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g., skin, intestine, lung, and ovary.
Isotype IgG
Reacitivity Human,Mouse
Clone
Uniprot P29317
Concentration 1mg/mL
Dilution WB 1:500-1:2000, ELISA 1:10000
Formulation
Application WB,ELISA
Other Names ARCC2,AW545284,CTPA,CTPP1,CTRCT6,EC 2.7.10.1,Eck,Eph receptor A2,EPHA2,EPHA2,Ephrin receptor,Ephrin receptor EphA2,Ephrin type A receptor 2,Ephrin type-A receptor 2,Epithelial cell kinase,Epithelial cell receptor protein tyrosine kinase,Myk 2,Myk2,Sek 2,Sek2,Soluble EPHA2 variant 1,Tyrosine protein kinase receptor ECK,Tyrosine-protein kinase receptor ECK,Tyrosine-protein kinase receptor MPK-5,Tyrosine-protein kinase receptor SEK-2
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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