Anti-Human/Mouse ALKBH2 Polyclonal Antibody

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine. Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA12872
Size 100μl
Host Type Rabbit
Immunogen Recombinant protein of human ALKBH2
Specificity Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder.
Isotype IgG
Reacitivity Human,Mouse
Clone
Uniprot Q6NS38
Concentration 0.4 mg/mL
Dilution WB 1:500-1:2000
Formulation
Application WB,ELISA
Other Names 2OG Fe(II) oxy DC1,9530023G02,ABH 2,ABH2,alkB alkylation repair homolog 2,ALKB2,ALKBH2 alkB,ALKBH2,Alkylated DNA repair protein alkB homolog,Alkylated DNA repair protein alkB homolog 2,Alkylation repair homolog 2,Alpha ketoglutarate dependent dioxygenase alkB homolog 2,Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2,AU016977,DNA oxidative demethylase ALKBH2,EC 1.14.11.,FLJ99103,hABH2,mABH2,MGC90512,Oxy DC1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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