Anti-Human/Monkey Phospho-CHEK2 (Ser516) Polyclonal Antibody

Categories: [ Antibodies][ Polyclonal Antibodies]

Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.

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Properties

Data Sheet	Click for Datasheet
Catalog Number	PA01528
Size	100μl
Host Type	Rabbit
Immunogen	Synthesized peptide derived from human Chk2 around the phosphorylation site of Ser516
Specificity	High expression is found in testis, spleen, colon and peripheral blood leukocytes. Low expression is found in other tissues.
Isotype	IgG
Reacitivity	Human,Monkey
Clone
Uniprot	O96017
Concentration	1mg/mL
Dilution	WB 1:500-1:2000, ELISA 1:10000
Formulation
Application	WB,ELISA
Other Names	CDS 1,Cds1,Cds1 homolog,Checkpoint kinase 2,Checkpoint like protein CHK2,CHEK 2,Chek2,Chk 2,CHK2 checkpoint homolog (S. pombe),CHK2 checkpoint homolog,CHK2,hCds1,HuCds 1,LFS 2,LFS2,PP1425,RAD 53,RAD53,Rad53 homolog,Serine/threonine protein kinase Chk2,Serine/threonine-protein kinase Chk2
Storage	Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript	For research use only, not for use in diagnostic procedures.

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Anti-Human/Monkey Phospho-CHEK2 (Ser516) Polyclonal Antibody

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