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Anti-Human CD109 Monoclonal Antibody

Categories: [ Antibodies][ Monoclonal Antibodies]
CD109,also named as CPAMD7,is a member of the alpha2-macroglobulin/complement superfamily. It is a glycosylphosphatidylinositol (GPI)-linked cell surface glycoprotein of approximately 170kd which is found on the cell surface of platelets,activated T-cells,and endothelial cells. CD109 binds to and negatively regulates signaling of transforming growth factor beta (TGF-beta). CD109 has been identified as part of the TGF-beta receptor system in human keratinocytes. Up regulation of CD109 expression has been observed in several different types of tumor. Multiple transcript variants encoding different isoforms have been found for CD109. The antibody can recognize all these 4 isoforms.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA01889
Size 100μl
Host Type Mouse
Immunogen Synthetic Peptide
Specificity Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34(+) acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 5 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta.
Isotype IgG1
Reacitivity Human
Clone 349
Uniprot Q6YHK3
Concentration None
Dilution WB 1:1000-1:10000
Formulation
Application WB,ELISA
Other Names 150 KDa TGF beta 1 binding protein,150 KDa TGF-beta-1-binding protein,7D1,8A3,Activated T cell marker CD109,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7,CD 109,CD109,CD109 antigen,CD109,CPAMD7,DKFZp762L1111,E123,FLJ38569,FLJ41966,Gov system alloantigens on platelets,p180,Platelet specific Gov antigen,Platelet-specific Gov antigen,r150,RP11 525G3.1
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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