Anti-Human BCL-x Monoclonal Antibody

BCL2L1 is a member of he BCL-2 protein family. BCL2L1 is expressed as two distinct isoforms,Bcl-xL and Bcl-xS,and is located at the outer mitochondrial membrane. The Bcl-XL isoform is a 233 amino acid protein,acting as an apoptotic inhibitor. Bcl-XL can forms heterodimers with BAX,BAK or BCL2,and the heterodimerization with BAX does not seem to be required for anti-apoptotic activity. The Bcl-XS isoform is a shorter variant that is 178 amino acids in length and lacks a 63 amino acid region (amino acids 126-188),acting as an apoptotic activator.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA01873
Size 100μl
Host Type Mouse
Immunogen Fusion protein of Bcl-XL
Specificity Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
Isotype IgG2b
Reacitivity Human
Clone
Uniprot Q07817
Concentration None
Dilution WB 1:2000-1:20000, IHC 1:20-1:200, IF 1:10-1:100
Formulation
Application WB,IHC,IF,ELISA
Other Names Apoptosis regulator Bcl X,Apoptosis regulator Bcl-X,Apoptosis regulator BclX,B cell lymphoma 2 like,B2CL1,Bcl 2 like 1 protein,Bcl X,Bcl xL,BCL XL/S,Bcl xS,Bcl-2-like protein 1,Bcl2 Like 1,Bcl2 related gene,Bcl2-L-1,BCL2L,Bcl2l1,BCLX,BclXL,BclXs,DKFZp781P2092,PPP1R52,Protein phosphatase 1 regulatory subunit 52
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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