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Anti-Human AK2 Monoclonal Antibody

Categories: [ Antibodies][ Monoclonal Antibodies]
AK2(Adenylate kinase 2,mitochondrial ) is also named as ADK2 and belongs to the adenylate kinase family. It plays a unique role in energy metabolism and energy transfer by regulating the ATP/ADP rate between the cytoplasma matrix and the mitochondria and it is increased expression during adipocyte and B cell differentiation. AK2 catalyzes the reversible transfer of a phosphoryl group from ATP to AMP. Defects in AK2 are the cause of reticular dysgenesis (RDYS). It has 6 isoforms produced by alternative splicing.
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Properties

Data Sheet Click for Datasheet
Catalog Number MA01843
Size 100μl
Host Type Mouse
Immunogen Fusion protein of AK2
Specificity Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level).
Isotype IgG2a
Reacitivity Human
Clone 205
Uniprot P54819
Concentration None
Dilution WB 1:1000-1:10000, IHC 1:20-1:200, IF 1:20-1:200
Formulation
Application WB,IHC,IF,ELISA
Other Names Adenylate kinase 2,adenylate kinase 2, mitochondrial,Adenylate kinase isoenzyme 2,ADK2,AK 2,ak2,ATP AMP transphosphorylase,ATP-AMP transphosphorylase 2,EC 2.7.4.3,KAD2,mitochondrial
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.
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