Anti-Human Acetyl-APEX1 (Lys6) Polyclonal Antibody

The role of transcription factors in the regulation of gene expression is well established. Although the activity of these factors can be regulated by phosphorylation,evidence has indicated regulation of DNA binding mediated by changes in reduction-oxidation (redox) status. Mutational analysis has identified a single conserved cysteine residue mapping within the DNA binding domains of Fos and Jun. Chemical oxidation or modification of this cysteine residue inhibits the DNA binding activity of Fos and Jun. A similar mode of regulation has been recently proposed for other nuclear transcription factors. Oxidation is reversible by these compounds or by a cellular redox/DNA repair protein identified originally as Ref-1 (redox factor 1). Ref-1 is identical to a previously characterized DNA repair enzyme designated HAP1, APE or APEX.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01417
Size 100μl
Host Type Rabbit
Immunogen Synthesized peptide derived from the human Ref-1 around the acetylation site of K6.
Specificity
Isotype IgG
Reacitivity Human
Clone
Uniprot P27695
Concentration 1mg/mL
Dilution WB 1:500-1:2000, IHC 1:100-300, ELISA 1:20000
Formulation
Application WB,IHC-p,ELISA
Other Names AP endonuclease 1,AP endonuclease class I,AP lyase,APE 1,APE,APE-1,APEN,APEX 1,APEX,APEX nuclease (multifunctional DNA repair enzyme) 1,Apex nuclease 1,APEX nuclease,APEX1,APEX1,Apurinic endonuclease,Apurinic-apyrimidinic endonuclease 1,Apurinic/apyrimidinic (abasic) endonuclease,Apurinic/apyrimidinic endonuclease 1,Apurinic/apyrimidinic exonuclease,APX,BAP1,Deoxyribonuclease (apurinic or apyrimidinic),DNA (apurinic or apyrimidinic site) lyase,DNA-(apurinic or apyrimidinic site) lyase,mitochondrial,EC 4.2.99.18,HAP 1,HAP1,Human Apurinic endonuclease 1,MGC139790,Multifunctional DNA repair enzyme,Redox factor 1,Redox factor-1,REF 1,REF 1 protein,REF-1,REF1,REF1 protein
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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