Amyloid Beta ( 1-43 ) Aβ Anti-Human Rabbit IgG Affinity Purify

Alzheimer's disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid (Aβ) peptide, a 40 to 43 amino acid peptide cleaved from amyloid precursor protein by β-secretase and γ-secretase. Increased release of Aβ42 or Aβ43, both of which exhibit a greater tendency to aggregate than Aβ40, occurs in individuals expressing certain genetic mutations, ApoE alleles or may involve other undiscovered factors. Many researchers theorize that it is this increased release of Aβ42/Aβ43 which leads to the abnormal deposition of Aβ and the associated neurotoxicity in the brains of affected individuals.
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Properties

Data Sheet Click for Datasheet
Catalog Number PA01045
Size 5 µg
Host Type Rabbit
Immunogen Synthetic peptide of the C terminal part of Human Amyloidβ43.
Specificity Human Amyloid Beta 43 specific. Doesn’t cross-react with human Amyloid Beta 40 or 42.
Isotype
Reacitivity Human
Clone
Uniprot
Concentration
Dilution
Formulation Lyophilized product from PBS containing 1 % BSA and 0.05 % NaN3.
Application IHC, WB.
Other Names Amyloid Beta, A-beta, Aβ.
Storage Lyophilized product: 5 years at 2 - 8°C; Solution: 2 years at -20°C.
Postscript For research use only, not for use in diagnostic procedures.

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