Recombinant Human SHH / Sonic hedgehog Protein (aa 1-197, His tag)

Categories: [Proteins / Peptides]
Sonic HedgeHog, also known as sonic hedgehog protein, belongs to the hedgehog family. It cannot be detected in adult tissues while can be found in fetal intestine, liver, lung, and kidney. Sonic HedgeHog is a protein that is vital in guding the early embryo. It has been associated as the major inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Sonic HedgeHog intercellular signal is essential for a various patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Sonic HedgeHog binds to the patched receptor, which functions in association with smoothened, to activate the transcription of target genes. In the absence of sonic HedgeHog, patched receptor represses the constitutive signaling activity of smoothened. Sonic HedgeHog also regulates another factor, the gli oncogene. Defects in sonic hedgehog can cause microphthalmia isolated with coloboma type 5, triphalangeal thumb-polysyndactyly syndrome and holoprosencephaly type 3.
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Properties

Data Sheet Click for Datasheet
Catalog Number TP04805
Size 20ug,50ug,100ug…
Host HEK293 Cells
Accession Q15465
Molecular Weight 21 kDa
AP_Mol_Weight 24 kDa
Tag C-His
Sequences Met 1-Gly 197
Purity > 95% by HPLC
Concentration
Formulation PBS
Other Names HHG1;HLP3;HPE3;MCOPCB5;SMMCI;Sonic hedgehog;TPT;TPTPS
Bioactivity Measured by its ability to induce alkaline phosphatase production by C3H10T1/2 mouse embryonic fibroblast cells. Nakamura, T. et al. (1997) Biochem. Biophys. Res. Commun.237:465.The ED50 for this effect is typically 2-10 μg/mL.
Storage Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Postscript For research use only, not for use in diagnostic procedures.

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