Recombinant Human OX40L Receptor Protein

Categories: [Proteins / Peptides]
OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
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Properties

Data Sheet Click for Datasheet
Catalog Number TP04738
Size 20ug,50ug,100ug…
Host Human Cells
Accession NP_003318.1
Molecular Weight 21.0 kDa
AP_Mol_Weight 35-40 kDa
Tag C-6His
Sequences Leu29-Ala216
Purity > 95% by HPLC
Concentration
Formulation PBS
Other Names Tumor necrosis factor receptor superfamily member 4;TNFRSF4;OX40;CD134;Txgp1
Bioactivity Measured by its binding ability in a functional ELISA. 2. Immobilized human TNFRSF4-his at 2 μg/mL (100 μl/well) can bind  human TNFSF4/mFc, The EC50 of human TNFSF4/mFc is 29 ng/mL.
Storage Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Postscript For research use only, not for use in diagnostic procedures.

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