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Recombinant Human Insulin-Like Growth Factor I/IGF-I/IGF1(4-70) Protein

Categories: [Proteins / Peptides]
Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor protein containing N-terminal and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids with 94% identity with mouse IGF1 and exhibits cross-species activity. IGF1 binds IGF-1R, IGF-2R, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF1 expression is regulated by growth hormone.
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Properties

Data Sheet Click for Datasheet
Catalog Number TP04605
Size 20ug,50ug,100ug…
Host E.coli
Accession P05019
Molecular Weight 7.3 kDa
AP_Mol_Weight 9 kDa
Tag
Sequences Thr52-Ala118
Purity > 95% by HPLC
Concentration
Formulation PBS
Other Names Insulin-Like Growth Factor I; IGF-I; Mechano Growth Factor; MGF; Somatomedin-C; IGF1; IBP1
Bioactivity Measured by its ability to induce NFKB reporter gene expression in HEK 293 cell line. Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cellsThe ED50 for this effect is less than 200 ng/ml.
Storage Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Postscript For research use only, not for use in diagnostic procedures.
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